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Título : Etiology of severe pneumonia in ecuadorian children
Autor : Jonnatagadda, Silvani
Rodríguez, Oswaldo
Estrella, Bertha
Sabin, Lora L.
Sempértegui, Fernando
Hamer, Davidson H.
Palabras clave : ENFERMEDADES EN NIÑOS
VACUNAS
NEUMONÍA
Fecha de publicación : 2017
Editorial : Estados Unidos: Plos
Citación : Jonnatagadda, Silvani y otros ( febrero 2017). Etiology of severe pneumonia in ecuadorian children. Revista Plos One, 12(2), pp. 1-19
Resumen : Background In Latin America, community-acquired pneumonia remains a major cause of morbidity and mortality among children. Few studies have examined the etiology of pneumonia in Ecuador. Methods This observational study was part of a randomized, double blind, placebo-controlled clinical trial conducted among children aged 2±59 months with severe pneumonia in Quito, Ecuador. Nasopharyngeal and blood samples were tested for bacterial and viral etiology by polymerase chain reaction. Risk factors for specific respiratory pathogens were also evaluated. Results Among 406 children tested, 159 (39.2%) had respiratory syncytial virus (RSV), 71 (17.5%) had human metapneumovirus (hMPV), and 62 (15.3%) had adenovirus. Streptococcus pneumoniae was identified in 37 (9.2%) samples and Mycoplasma pneumoniae in three (0.74%) samples. The yearly circulation pattern of RSV (P = 0.0003) overlapped with S. pneumoniae, (P = 0.03) with most cases occurring in the rainy season. In multivariable analysis, risk factors for RSV included younger age (adjusted odds ratio [aOR] = 1.9, P = 0.01) and being underweight (aOR = 1.8, P = 0.04). Maternal education (aOR = 0.82, P = 0.003), pulse oximetry (aOR = 0.93, P = 0.005), and rales (aOR = 0.25, P = 0.007) were associated with influenza A. Younger age (aOR = 3.5, P = 0.007) and elevated baseline respiratory rate were associated with HPIV-3 infection (aOR = 0.94, P = 0.03). Conclusion These results indicate the importance of RSV and influenza, and potentially modifiable risk factors including undernutrition and future use of a RSV vaccine, when an effective vaccine becomes available.
URI : http://www.dspace.uce.edu.ec/handle/25000/13676
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