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Título : The role of mobile genetic elements in the spread of antimicrobial resistant escherichia coli from chickens to humans in small-scale production poultry operations in rural Ecuador
Autor : Moser, Kara A.
Zhang, Lixin
Spicknall, Ian
P. Braykov, Nikolay
Foxman, Betsy
Levey, Karen
F. Marrs, Carl
Trueba, Gabriel
Cevallos, William
Goldstick, Jason
Trostle, James
N. S. Eisenberg, Joseph
Palabras clave : RESISTENCIA A LOS ANTIMICROBIANOS
PRODUCCIÓN DE AVES DE CORRAL
ESCHERICHIA COLI
Fecha de publicación : 2017
Editorial : [s.d.t.]
Citación : Moser, Karen A. y otros (2017). The role of mobile genetic elements in the spread of antimicrobial resistant escherichia coli from chickens to humans in small-scale production poultry operations in rural Ecuador. Oxford University. (1-30)
Resumen : Small-scale production poultry operations are increasingly common worldwide. To investigate how these operations influence antimicrobial resistance and mobile genetic elements (MGEs), E. coli isolates were sampled from small-scale production birds (raised in confined spaces with antibiotics in feed), household birds (no movement constraints; fed on scraps), and humans associated with these birds in rural Ecuador (2010-2012). Isolates were screened for genes associated with MGEs as well as phenotypic resistance to 12 antibiotics. Isolates from small-scale production birds had significantly elevated odds of resistance to seven antibiotics and all MGE genes compared to household birds (adjusted odds ratio (aOR) range: 2.2-87.9). Isolates from humans associated with small-scale production birds had elevated odds of carrying an integron (aOR=2.0; 95% confidence interval (CI): 1.06, 3.83) compared to humans associated with household birds, as well as sulfisoxazole (aOR=1.9; 95% CI: 1.01, 3.60) and trimethoprim/sulfamethoxazole (aOR=2.1; 95% CI: 1.13, 3.95) resistance. Stratifying by the presence of MGEs revealed antibiotic groups that are explained by biological links to MGEs; in particular, sulfisoxazole, trimethoprim/sulfamethoxazole, and tetracycline resistance were highest among birds and humans when MGE exposures were present. Small-scale production poultry operations may select for isolates carrying MGEs, contributing to elevated levels of resistance in this setting.
URI : http://www.dspace.uce.edu.ec/handle/25000/14630
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