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Título : Bayesian modelling to estimate the test characteristics of coprology, coproantigen ELISA and a novel real-time PCR for the diagnosis of taeniasis
Autor : Praet, Nicolas
Phiri, Isaac
Rodríguez Hidalgo, Richar
Benitez Ortiz, Washington Vicente
Sarah, Gabriel
Palabras clave : TAENIASIS
TAENIA SOLIUM
METODOLOGÍA BAYESIANA
Fecha de publicación : 2013
Editorial : Nueva Jersey: Blackwell Publishing Ltd
Citación : Benitez Ortiz, Washington y otros (2013). Bayesian modelling to estimate the test characteristics of coprology, coproantigen ELISA and a novel real-time PCR for the diagnosis of taeniasis. Tropical Medicine and International Health, 18(5): 608-614
Resumen : objective To estimate and compare the performances of coprology, copro-Ag ELISA and real-time polymerase chain reaction assay (copro-PCR) for detection of Taenia solium tapeworm carriers. methods The three diagnostic tests were applied on 817 stool samples collected in two Zambian communities where taeniasis is endemic. A Bayesian approach was used to allow estimation of the test characteristics. Two (0.2%; 95% Confidence Interval (CI): 0–0.8), 67 (8.2%; 95% CI: 6.4–10.3) and 10 (1.2%; 95% CI: 0.5–2.2) samples were positive using coprology, copro-Ag ELISA and coproPCR, respectively. results Specificities of 99.9%, 92.0% and 99.0% were determined for coprology, copro-Ag ELISA and copro-PCR, respectively. Sensitivities of 52.5%, 84.5% and 82.7% were determined for coprology, copro-Ag ELISA and copro-PCR, respectively. conclusions We urge for additional studies exploring possible cross-reactions of the copro-Ag ELISA and for the use of more sensitive tests, such as copro-PCR, for the detection of tapeworm carriers, which is a key factor in controlling the parasite in endemic areas.
URI : http://www.dspace.uce.edu.ec/handle/25000/14631
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