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Título : Unacylated ghrelin modulates circulating angiogenic cell number in insulin-resistant states
Autor : Baldeón Rojas, Lucy Yadira
Ozcam, Behiye
Leenen, Pieter J. M.
Delhanty, Patric J. D.
Neggers, Sebastian J.
Jan van der Lely, Aart
Palabras clave : DIABETES
Fecha de publicación : 2017
Editorial : Sao Paulo: Sociedade Brasileira de Diabetes
Citación : Baldeón Rojas, Lucy Yadira y otros (2017). Unacylated ghrelin modulates circulating angiogenic cell number in insulin-resistant states. Diabetology & Metabolic Syndrome, 9(43): 1-9.
Resumen : Background: Type 2 diabetes (T2D) is associated with reduced numbers and impaired function of circulating angiogenic cells (CAC) which contributes to the progression of atherosclerosis and microvascular disease. Previous studies suggest that short-term infusion of unacylated ghrelin (UAG) normalizes CAC number in patients with T2D. To determine dose-dependent efects of short-term infusion of UAG in T2D patients using a cross-over model, and of long-term infusion of UAG in obese mice, on diferentiation of monocyte progenitors into CAC. Methods: Eight overweight T2D patients were infused overnight with 3 and 10 µg/kg/h of UAG in a double-blind, placebo-controlled cross-over study. To assess the efects of long-term UAG treatment, obese mice were infused with UAG for 4 weeks. Monocyte progenitors were assessed for their ability to diferentiate into CAC in vitro. Results: In T2D patients, UAG treatment caused a reduction in diferentiation of CAC, dependent on UAG dose and diferentiation method. However, mice treated with UAG showed a signifcant increase in diferentiation of bone mar‑ row progenitors into CAC. Conclusion: UAG causes a minor suppressive efect on CAC development after short-term treatment in humans, but experiments in mice suggest that long-term treatment has benefcial efects on CAC formation.
URI : http://www.dspace.uce.edu.ec/handle/25000/14928
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