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Título : Comparison of complementary diagnostic tests in cerebrospinal fluid and serum for neurocysticercosis
Autor : Rodríguez-Hidalgo, Richar
Romo, Matthew L
Carpio, Arturo
Parkhouse, Michael
Cortéz, María
Palabras clave : EVIDENCE-BASED MEDICINE
INFECTIOUS DISEASE
NEUROLOGY
Fecha de publicación : 27-nov-2018
Editorial : Quito
Citación : Matthew L. Romo, Arturo Carpio, R. Michael E. Parkhouse, María Milagros Cort ez, Richar Rodríguez-Hidalgo. (2018) Comparison of complementary diagnostic tests in cerebrospinal fluid and serum for neurocysticercosis. Heliyon 4
Resumen : he diagnosis of NC. We conducted a case-control study in Cuenca, Ecuador, enrolling patients with NC (N ¼ 24) and matching them with other neurosurgical patients (N ¼ 18). To detect cysticercal antigen, we used an HP10 antigen assay in serum and CSF (“HP10 Ag -serum -CSF”) and a commercial antigen assay in serum (apDia, “ELISA-Ag-serum”), and to detect cysticercal DNA, we used a polymerase chain reaction (PCR) assay in CSF (“PCR-CSF”). Assay sensitivities were: HP10 Ag-serum (41.7%, 95% confidence interval [CI] 22.1e63.4), HP10 Ag-CSF (87.5%, 95% CI: 67.6e97.3), ELISA-Ag-serum (62.5%, 95% CI: 40.6e81.2), and PCR-CSF (79.2%, 95% CI: 57.9e92.9). Sensitivities were higher when limiting to participants with extraparenchymal NC. Specificity was 100% for all assays except ELISA-Agserum (72.2%). This preliminary study demonstrated the potential usefulness of the PCR and HP10 Ag assay in CSF, especially for extraparenchymal NC; thus, they could be considered as complementary diagnostic tools when neuroimaging is not conclusive.
URI : http://www.dspace.uce.edu.ec/handle/25000/17267
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