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Título : T. cruzi seroprevalence in ecuadorian pregnant women
Autor : Costales, Jaime A.
Sánchez-Gómez, Amaya
Silva-Aycaguer, Luis C.
Cevallos, William
Tamayo, Susana
Yumiseva, César A.
Jacobson, Jerry O.
Martini, Luiggi
Carrera, Caty A.
Grijalva, Mario J.
Fecha de publicación : 9-feb-2015
Editorial : Ohio: American Society of Tropical Medicine and Hygiene
Citación : Costales, Jaime A. y otros (febrero 2015). American Society of Tropical Medicine and Hygiene. Revista American Journal of Tropical Medicine and Hygiene, pp. 1-8
Resumen : A nationwide survey was conducted to obtain an estimate of Chagas disease prevalence among pregnant women in Ecuador. As part of a national probability sample, 5,420 women seeking care for delivery or miscarriage at 15 healthcare facilities were recruited into the study. A small minority of participants reported knowing about Chagas disease or recognized the vector. A national seroprevalence of 0.1% (95% confidence interval [95% CI] = 0.0–0.2%) was found; cases were concentrated in the coastal region (seroprevalence = 0.2%; 95% CI = 0.0–0.4%). No cases of transmission to neonates were identified in the sample. Seropositive participants were referred to the National Chagas Program for evaluation and treatment. Additional studies are necessary to determine if areas of higher prevalence exist in well-known endemic provinces and guide the development of a national strategy for elimination of mother-to-child transmission of Chagas disease in Ecuador. Chagas disease, caused by Trypanosoma cruzi, is spread mainly by hematophagous triatomine vectors, blood transfusion, and congenital transmission.1 It is estimated that 200,000 people are infected with T. cruzi in Ecuador,2 where most provinces located on the Pacific coast as well Loja in the southern highlands have, for many decades, been known to be endemic for Chagas disease and continue to be active transmission foci.3,4 Meanwhile, sylvatic foci were detected in the northern Ecuadorian Amazon region during the 1990s,5 and additional studies have shown that this region is very active for T. cruzi transmission.6–8 However, despite punctual knowledge at the local scale, the global epidemiological situation of Chagas disease in Ecuador remains largely uncharacterized: no country-wide study exists to provide a global estimate of prevalence for T. cruzi infection, many areas remain unstudied, and particularly little is known regarding congenital transmission. Five percent of T. cruzi-infected pregnant women transmit Chagas disease to their offspring congenitally,9 and over 15,000 such cases are estimated to occur yearly in Latin America.10 Screening of pregnant women in endemic areas for infection with T. cruzi is recommended.11 Furthermore, because of human migration, congenital Chagas
URI : http://www.dspace.uce.edu.ec/handle/25000/4437
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