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|Título :||The effects of selection pressure and genetic association on the relationship between antibiotic resistance and virulence in Escherichia coli|
|Autor :||Levy, Karen|
Marrs, Carl F.
Eisembreg, Joseph N. S.
|Palabras clave :||AGENTES ANTIBACTERIANOS|
|Fecha de publicación :||17-ago-2015|
|Editorial :||Estados Unidos: Sociedad Americana de Microbiología.|
|Citación :||Levy, Karen; Trueba, Gabriel y Cevallos, Williamn y otros (2015). The effects of selection pressure and genetic association on the relationship between antibiotic. Revista Antimicrob Agents Chemother, 28 p.|
|Resumen :||Antibiotic selection pressure and genetic associations may lead to the co-occurrence of resistance and virulence in individual pathogens. However, there is a lack of rigorous epidemiological evidence that demonstrates co-occurrence of resistance and virulence at the population level. Using samples from a population-based case-control study in villages in rural Ecuador, we characterized resistance to antibiotics among pathogenic (n=86) and commensal (n=761) E. coli isolates, classified by the presence or absence of known diarrheagenic virulence factor genes. Prevalence of resistance to single and multiple antibiotics was significantly higher in pathogenic compared to commensal isolates. Using a generalized estimating equation, antibiotic resistance was independently associated with virulence factor carriage, case status and antibiotic use (OR = 3.0, 95% CI (1.7 – 5.1); OR = 2.0, 95% CI (1.3 – 3.0); OR = 1.5, 95% CI (0.9 – 2.5) respectively). Virulence factor carriage was more strongly related to antibiotic resistance than antibiotic use for all antibiotics examined, with the exception of fluoroquinolones, gentamicin, and cefotaxime. This study provides epidemiological evidence that antibiotic resistance and virulence factor carriage are linked in E. coli populations in a community setting. Further, these data suggest that, while the co-occurrence of resistance and virulence in E. coli is partially due to antibiotic selection pressure, it is also genetically determined. These findings should be considered when developing strategies for treating infections and controlling for antibiotic resistance.|
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